Supporting Information Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into co-operativity, priming and irreversibility
نویسندگان
چکیده
In this Supporting Information we provide the following additional details: • Bistability of the PU.1–GATA-1 system – mathematical aspects. • An irreversible bistable PU.1–GATA-1 switch. • Is it necessary for C/EBPα to be autoregulating for irreversibility of the network? • Consequences of autoregulation of FOG-1 for the PU.1–GATA-1 switch. • Can FOG-1 play the role of the X gene? • Circuit properties of the GATA-1–PU.1 switch due to self-association of GATA-1.
منابع مشابه
Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility
Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. However, prior to lineage commitment, genes are primed at low expression levels. Understanding the underlying molecular circuitry in terms of how it governs both a primed state and, at the other extreme, a committed state is of relevance not only to hematopoiesis but also to d...
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